2020

Valle-Tenney R, Rebolledo D.L., Acuña MJ, Brandan E. (2020) HIF-hypoxia signaling in skeletal muscle physiology and fibrosis. J Cell Commun Signal. doi: 10.1007/s12079-020-00553-8.

 

Valle-Tenney R, Rebolledo D.L., Lipson K.E., Brandan E. (2019) Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers. Matrix Biol. doi: 10.1016/j.matbio.2019.09.003

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2019

Contreras O, Cruz-Soca M, Theret M, Soliman H, Tung LW, Groppa E, Rossi F.M., Brandan E. (2019) The cross-talk between TGF-β and PDGFRα signaling pathways regulates stromal fibro/adipogenic progenitors' fate. J Cell Sci. doi: 10.1242/jcs.232157.

 

Contreras, O., Rossi, F.M., Brandan, E. (2019) Adherent muscle connective tissue fibroblasts are phenotypically and biochemically equivalent to stromal fibro/adipogenic progenitors. Matrix Biol. Plus. Vol 2, Article 100006.

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Gonzalez, D and Brandan, E (2019) CTGF/CCN2 from skeletal muscle to nervous system: impact on neurodegenerative diseases.

Mol. Neurobiol. In Press doi.org/10.1007/s12035-019-1490-9

 

Rebolledo, D.L., González, D., Faundez-Contreras, J., Contreras, O., Murphy-Ullrich, J.E., Lipson, K.E. and Brandan, E. (2019) CTGF/CCN2 Modulates Denervation-induced Skeletal Muscle Fibrosis independently of TGF-b. Matrix Biol. doi: 10.1016/j.matbio.2019.01.002.

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2018

Gonzalez D, Rebolledo DL, Correa LM, Court F, Cerpa W, Lipson KE, van Zundert B, Brandan E (2018) The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum Mol Genet. 2018 May 30. doi: 10.1093/hmg/ddy204

 

Contreras, O., Villarreal, M. and Brandan, E. (2018) Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skelet Muscle 20;8(1):5.

 

Riquelme-Guzmán, C., Contreras O., and Brandan E. (2018) Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. Am. J. Physiol. Cell Physiol.314, C415-C427.

 

Acuña, MJ., Salas, D., Cordova-Casanova, A., Cruz-Soca, A., Céspedes, C, Vío, C.P. and Brandan, E (2018) Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors. J Cell Commun Signal. doi: 10.1007/s12079-017-0439-x.

 

Morales, M.G., Acuña, M.J., Cabrera, D.,  Goldschmeding, R and Brandan E. (2018) The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle. J Cell Commun Signal. doi: 10.1007/s12079-017-0409-3.

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2017

Contreras O, Brandan E. (2017) Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. J Cell Commun Signal. (2017) 11:77-78.

 

Cabrera, D., Wree, A., Povero, D., Solis, N., Hernandez, A., Pizarro, A, Moshage, H., Torres, J., Feldstein, A., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. Arrese, M. (2017) Andrographolide ameliorates inflammation and fibrogenesis and attenuates inflammasome activation in experimental non-alcoholic steatohepatitis. Sci Rep.  14;7(1):349.1doi: 10.1038/s41598-017-03675-z.

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Gonzalez, D., Contreras, O., Rebolledo, DL., Espinoza, JP., van Zundert, B., Brandan E. (2017) ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS One 16;12(5):e0177649. doi: 10.1371/journal.pone.0177649.

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2016

Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. Contreras O, Brandan E. J Cell Commun Signal. (2016) Dec 20. doi: 10.1007/s12079-016-0372-4.

 

Contreras, O., Rebolledo, D.L. Oyarzún, J.E., Olguín, H. and Brandan, E. (2016) Connective tissue cells expressing fibro/adipogenic progenitors markers increase under chronic damage; Relevance to fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell Tissue Res. 364, 647-60.

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Morales, M.G., Abrigo, J., Acuña, M.J., Santos, R., Bader, M, Brandan, E, Simon, F., Olgin, H., Cabrera, D. and Cabello-Verrugio, C.  (2016). Ang 1-7 decreases muscle wasting by disuse. Dis Model Mech 9, 441-449.

 

Fuenzalida, M., Espinoza, C., Pérez, M.A. Tapia-Rojas, Ch., Cuitino, L., Brandan, E. Inestrosa, N.C. (2016) Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Neurobiol. Dis. 86, 109-20

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Cabrera, D., Ruiz, A., Cabello-Verrugio, C., Brandan, E., Estrada, L., Pizarro, M., Solis, N., Torres, J., Barrera, F., and Arrese, M. (2016) Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1. Dig. Dis. Sci. DOI 10.1007/s10620-016-4285-0

 

2015  

Gutiérrez, J*., Droppelmann, CA.,  Contreras, O., Takahashi, C., and Brandan, E*. (2015) RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice. PLoS One 2015 Aug 6;10(8):e0135005. doi: 10.1371/journal.pone.0135005. (*Both corresponding authors).

 

Cofre, C., Acuña, M.J., Contreras, O., Morales, M.G., Riquelme, C., Cabello-Verrugio, C. and Brandan, E. (2015) Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies. BioFactors, 41, 111-20.

 

Passos-Silva, D., Brandan, E. and Souza Santos, RA. (2015) Angiotensins as therapeutic targets beyond heart disease. Trends  Pharmacol. Sci. 36, 310-320

 

Córdova G, Rochard A, Riquelme-Guzmán C, Cofré C, Scherman D, Bigey P, Brandan E. (2015) SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth

Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β. J. Cell. Biochem. 116, 1880-7

 

Brandan E. (2015). Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion. J Cell Commun Signal. 9,89.

 

Cisternas, F., Morales, M.G., Meneses, C., Dimon, F., Brandan, E., Abrigo, J, Vazquez Y and Cabello-Verrugio, C. (2015). Angiotensin 1-7 Decreases Skeletal Muscle Atrophy induced by Angiotensin II through Mas Receptor Dependent Mechanism. Clin Sci (Lond). 128,307-19.

 

Meneses C, Morales MG, Abrigo J, Simon F, Brandan E, Cabello-Verrugio C.The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice. (2015) Pflugers Arch. 467, 1975-84.

 

2014

Acuña MJ, Pessina P, Olguin H, Cabrera D, Vio CP, Bader M, Muñoz-Canoves P, Santos RA, Cabello-Verrugio C, Brandan E. (2014). Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling.Hum Mol Genet. 23, 1237-49

 

Gutierrez, J., Cabrera, D., and Brandan, E. (2014) Glypican-1 regulates myoblast response to HGF via met in a lipid raft-dependent mechanism: Effect on migration of skeletal muscle precursor cells. Skeletal Muscle 2014, 4:5

 

Pessina, P., Cabrera, D., Morales, MG., Riquelme, CA., Gutiérrez, J., Serrano, AL., Brandan, E. and Muñoz-Cánoves, P. (2014) Novel and optimized strategies for inducingfibrosis in vivo: focus on Duchenne Muscular Dystrophy. Skeletal Muscle 2014, 4:7

 

Cabrera, D., Gutiérrez, J. Cabello-Verrugio, C., Morales, M.G., Mezzano, S.,Hancke, J. and Brandan, E. (2014) Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis. Skeletal Muscle, 4:6

 

Riquelme, CA., Acuña, MJ., Torrejón, J., Rebolledo, D., Cabrera, D., Santos, RA. and Brandan, E. (2014) .ACE2 is augmented in dystrophic skeletal muscle and plays a role in decreasing associated fibrosis. PLoS One Apr 2;9(4):e93449. doi: 10.1371/journal.pone.0093449. 

 

Cisternas, P., Henríquez, J.P., Brandan, E. and Inestrosa, NC. (2014) Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis

Mol. Neurobiol. 49, 574-89.

 

2013                                                                                                                                                                

Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E. (2013). Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Hum Mol Genet. 15, 4938-512.

 

Calligaris, SD., Lecanda, M., Solis, F., Ezquer, M., Gutiérrez, J., Brandan, E., Leiva, A., Sobrevia, L., Conget, P. (2013) Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy. Plos.One 8(4):e60931

 

Painemal P, Acuña MJ, Riquelme C, Brandan E*, Cabello-Verrugio C*. (2013) Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle. Biofactors. 39, 467-475.

 

Brandan, E and Gutierrez, J. (2013) Role of proteoglycans in the regulation of skeletal muscle fibrotic response.FEBS J. 280, 4109-4117

 

Brandan, E and Gutierrez, J. (2013) Role of skeletal muscle proteoglycans during myogenesis. Matrix Biol. 32, 289-297

 

Morales, G., Cabrera, D., Céspedes, C., Vio, C., Vázquez, Y., Brandan, E., and Cabello-Verrugio, C. (2013). Inhibition of angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution on the expression and activity of connective tissue growth factor (CTGF/CCN-2) Cell Tiss Res 353, 173-87

 

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