2021

Rebolledo,  D.L.,  Acuña, M.J. and Brandan, E. (2021) Role of matricellular CCN proteins in skeletal muscle: Focus on CCN2/CTGF and its regulation by vasoactive peptides.

Int J Mol Sci. (In press)

Contreras, O., Cordova-Casanova, A. and Brandan, E. (2021) PDGF-PDGFR Network Differentially Regulates Myogenic Cell Fate, Migration, Proliferation, and Cell Cycle Progression.

Cell Signal, doi: 10.1016/j.cellsig.2021.110036

 

Rebolledo, D., Lipson, KE, and Brandan, E. (2021) Driving Fibrosis in Neuromuscular Diseases: Role and Regulation of Connective Tissue Growth Factor (CCN2/CTGF) Matrix Biol Plus doi.org/10.1016/j.mbplus.2021.100059

  

Gallardo, F.S., Córdova-Casanova, A., and Brandan, E. (2021) The Linkage Between Inflammation and Fibrosis in Muscular Dystrophies: The Axis Autotaxin-Lysophosphatidic Acid as a New Therapeutic Target? J. Cell Commun. Signal. doi.org/10.1007/s12079-021-00610-w

 

Gutiérrez, J., Gonzalez, D., Escalona, R., Takahashi, C., and Brandan, E. (2021) Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration and decrease fibrosis. Faseb J. In Press

2020

Rivera, JC., Abriigo, J., Tacchi, F., Simon, F., Brandan, E., Santos, RA. Bader,M.,  Chiong, M., and Cabello-Verrugio, C. (2020) Angiotensin-(1-7) Prevents Lipopolysaccharide-induced Autophagy via the Mas Receptor.Int J Mol Sci. 21(24), 9344    doi: 10.3390/ijms21249344

Contreras, O., Soliman, H., Theret, M., Rossi, F.M., and Brandan, E. (2020) TGF-b-driven downregulation of the Wnt/b-Catenin transcription factor TCF7L2/TCF4 in PDGFRa+ fibroblasts. J. Cell Sci. 133, jcs242297. doi: 10.1242/jcs.242297

 

Valle-Tenney R, Rebolledo D.L., Acuña MJ, Brandan E. (2020) HIF-hypoxia signaling in skeletal muscle physiology and fibrosis. J Cell Commun Signal. 14:147-158.

 

Valle-Tenney R, Rebolledo D.L., Lipson K.E., Brandan E. (2020) Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers. Matrix Biol. 87:48-65

2019

Contreras O, Cruz-Soca M, Theret M, Soliman H, Tung LW, Groppa E, Rossi F.M., Brandan E. (2019) The cross-talk between TGF-β and PDGFRα signaling pathways regulates stromal fibro/adipogenic progenitors' fate. J Cell Sci. doi: 10.1242/jcs.232157.

 

Contreras, O., Rossi, F.M., Brandan, E. (2019) Adherent muscle connective tissue fibroblasts are phenotypically and biochemically equivalent to stromal fibro/adipogenic progenitors. Matrix Biol. Plus. Vol 2, Article 100006.

Gonzalez, D and Brandan, E (2019) CTGF/CCN2 from skeletal muscle to nervous system: impact on neurodegenerative diseases.

Mol. Neurobiol. In Press doi.org/10.1007/s12035-019-1490-9

 

Rebolledo, D.L., González, D., Faundez-Contreras, J., Contreras, O., Murphy-Ullrich, J.E., Lipson, K.E. and Brandan, E. (2019) CTGF/CCN2 Modulates Denervation-induced Skeletal Muscle Fibrosis independently of TGF-b. Matrix Biol. doi: 10.1016/j.matbio.2019.01.002.

2018

Gonzalez D, Rebolledo DL, Correa LM, Court F, Cerpa W, Lipson KE, van Zundert B, Brandan E (2018) The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum Mol Genet. 2018 May 30. doi: 10.1093/hmg/ddy204

 

Contreras, O., Villarreal, M. and Brandan, E. (2018) Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skelet Muscle 20;8(1):5.

 

Riquelme-Guzmán, C., Contreras O., and Brandan E. (2018) Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. Am. J. Physiol. Cell Physiol.314, C415-C427.

 

Acuña, MJ., Salas, D., Cordova-Casanova, A., Cruz-Soca, A., Céspedes, C, Vío, C.P. and Brandan, E (2018) Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors. J Cell Commun Signal. doi: 10.1007/s12079-017-0439-x.

 

Morales, M.G., Acuña, M.J., Cabrera, D.,  Goldschmeding, R and Brandan E. (2018) The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle. J Cell Commun Signal. doi: 10.1007/s12079-017-0409-3.

2017

Contreras O, Brandan E. (2017) Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. J Cell Commun Signal. (2017) 11:77-78.

 

Cabrera, D., Wree, A., Povero, D., Solis, N., Hernandez, A., Pizarro, A, Moshage, H., Torres, J., Feldstein, A., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. Arrese, M. (2017) Andrographolide ameliorates inflammation and fibrogenesis and attenuates inflammasome activation in experimental non-alcoholic steatohepatitis. Sci Rep.  14;7(1):349.1doi: 10.1038/s41598-017-03675-z.

Gonzalez, D., Contreras, O., Rebolledo, DL., Espinoza, JP., van Zundert, B., Brandan E. (2017) ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS One 16;12(5):e0177649. doi: 10.1371/journal.pone.0177649.

2016

Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. Contreras O, Brandan E. J Cell Commun Signal. (2016) Dec 20. doi: 10.1007/s12079-016-0372-4.

 

Contreras, O., Rebolledo, D.L. Oyarzún, J.E., Olguín, H. and Brandan, E. (2016) Connective tissue cells expressing fibro/adipogenic progenitors markers increase under chronic damage; Relevance to fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell Tissue Res. 364, 647-60.

Morales, M.G., Abrigo, J., Acuña, M.J., Santos, R., Bader, M, Brandan, E, Simon, F., Olgin, H., Cabrera, D. and Cabello-Verrugio, C.  (2016). Ang 1-7 decreases muscle wasting by disuse. Dis Model Mech 9, 441-449.

 

Fuenzalida, M., Espinoza, C., Pérez, M.A. Tapia-Rojas, Ch., Cuitino, L., Brandan, E. Inestrosa, N.C. (2016) Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Neurobiol. Dis. 86, 109-20

Cabrera, D., Ruiz, A., Cabello-Verrugio, C., Brandan, E., Estrada, L., Pizarro, M., Solis, N., Torres, J., Barrera, F., and Arrese, M. (2016) Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1. Dig. Dis. Sci. DOI 10.1007/s10620-016-4285-0

 

2015  

Gutiérrez, J*., Droppelmann, CA.,  Contreras, O., Takahashi, C., and Brandan, E*. (2015) RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice. PLoS One 2015 Aug 6;10(8):e0135005. doi: 10.1371/journal.pone.0135005. (*Both corresponding authors).

 

Cofre, C., Acuña, M.J., Contreras, O., Morales, M.G., Riquelme, C., Cabello-Verrugio, C. and Brandan, E. (2015) Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies. BioFactors, 41, 111-20.

 

Passos-Silva, D., Brandan, E. and Souza Santos, RA. (2015) Angiotensins as therapeutic targets beyond heart disease. Trends  Pharmacol. Sci. 36, 310-320

 

Córdova G, Rochard A, Riquelme-Guzmán C, Cofré C, Scherman D, Bigey P, Brandan E. (2015) SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth

Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β. J. Cell. Biochem. 116, 1880-7

 

Brandan E. (2015). Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion. J Cell Commun Signal. 9,89.

 

Cisternas, F., Morales, M.G., Meneses, C., Dimon, F., Brandan, E., Abrigo, J, Vazquez Y and Cabello-Verrugio, C. (2015). Angiotensin 1-7 Decreases Skeletal Muscle Atrophy induced by Angiotensin II through Mas Receptor Dependent Mechanism. Clin Sci (Lond). 128,307-19.

 

Meneses C, Morales MG, Abrigo J, Simon F, Brandan E, Cabello-Verrugio C.The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice. (2015) Pflugers Arch. 467, 1975-84.

 

2014

Acuña MJ, Pessina P, Olguin H, Cabrera D, Vio CP, Bader M, Muñoz-Canoves P, Santos RA, Cabello-Verrugio C, Brandan E. (2014). Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling.Hum Mol Genet. 23, 1237-49

 

Gutierrez, J., Cabrera, D., and Brandan, E. (2014) Glypican-1 regulates myoblast response to HGF via met in a lipid raft-dependent mechanism: Effect on migration of skeletal muscle precursor cells. Skeletal Muscle 2014, 4:5

 

Pessina, P., Cabrera, D., Morales, MG., Riquelme, CA., Gutiérrez, J., Serrano, AL., Brandan, E. and Muñoz-Cánoves, P. (2014) Novel and optimized strategies for inducingfibrosis in vivo: focus on Duchenne Muscular Dystrophy. Skeletal Muscle 2014, 4:7

 

Cabrera, D., Gutiérrez, J. Cabello-Verrugio, C., Morales, M.G., Mezzano, S.,Hancke, J. and Brandan, E. (2014) Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis. Skeletal Muscle, 4:6

 

Riquelme, CA., Acuña, MJ., Torrejón, J., Rebolledo, D., Cabrera, D., Santos, RA. and Brandan, E. (2014) .ACE2 is augmented in dystrophic skeletal muscle and plays a role in decreasing associated fibrosis. PLoS One Apr 2;9(4):e93449. doi: 10.1371/journal.pone.0093449. 

 

Cisternas, P., Henríquez, J.P., Brandan, E. and Inestrosa, NC. (2014) Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis

Mol. Neurobiol. 49, 574-89.

 

2013                                                                                                                                                                

Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E. (2013). Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Hum Mol Genet. 15, 4938-512.

 

Calligaris, SD., Lecanda, M., Solis, F., Ezquer, M., Gutiérrez, J., Brandan, E., Leiva, A., Sobrevia, L., Conget, P. (2013) Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy. Plos.One 8(4):e60931

 

Painemal P, Acuña MJ, Riquelme C, Brandan E*, Cabello-Verrugio C*. (2013) Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle. Biofactors. 39, 467-475.

 

Brandan, E and Gutierrez, J. (2013) Role of proteoglycans in the regulation of skeletal muscle fibrotic response.FEBS J. 280, 4109-4117

 

Brandan, E and Gutierrez, J. (2013) Role of skeletal muscle proteoglycans during myogenesis. Matrix Biol. 32, 289-297

 

Morales, G., Cabrera, D., Céspedes, C., Vio, C., Vázquez, Y., Brandan, E., and Cabello-Verrugio, C. (2013). Inhibition of angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution on the expression and activity of connective tissue growth factor (CTGF/CCN-2) Cell Tiss Res 353, 173-87