2021
Rebolledo, D.L., Acuña, M.J. and Brandan, E. (2021) Role of matricellular CCN proteins in skeletal muscle: Focus on CCN2/CTGF and its regulation by vasoactive peptides.
Int J Mol Sci. (In press)
Contreras, O., Cordova-Casanova, A. and Brandan, E. (2021) PDGF-PDGFR Network Differentially Regulates Myogenic Cell Fate, Migration, Proliferation, and Cell Cycle Progression.
Cell Signal, doi: 10.1016/j.cellsig.2021.110036
Rebolledo, D., Lipson, KE, and Brandan, E. (2021) Driving Fibrosis in Neuromuscular Diseases: Role and Regulation of Connective Tissue Growth Factor (CCN2/CTGF) Matrix Biol Plus doi.org/10.1016/j.mbplus.2021.100059
Gallardo, F.S., Córdova-Casanova, A., and Brandan, E. (2021) The Linkage Between Inflammation and Fibrosis in Muscular Dystrophies: The Axis Autotaxin-Lysophosphatidic Acid as a New Therapeutic Target? J. Cell Commun. Signal. doi.org/10.1007/s12079-021-00610-w
Gutiérrez, J., Gonzalez, D., Escalona, R., Takahashi, C., and Brandan, E. (2021) Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration and decrease fibrosis. Faseb J. In Press
2020
Rivera, JC., Abriigo, J., Tacchi, F., Simon, F., Brandan, E., Santos, RA. Bader,M., Chiong, M., and Cabello-Verrugio, C. (2020) Angiotensin-(1-7) Prevents Lipopolysaccharide-induced Autophagy via the Mas Receptor.Int J Mol Sci. 21(24), 9344 doi: 10.3390/ijms21249344
Contreras, O., Soliman, H., Theret, M., Rossi, F.M., and Brandan, E. (2020) TGF-b-driven downregulation of the Wnt/b-Catenin transcription factor TCF7L2/TCF4 in PDGFRa+ fibroblasts. J. Cell Sci. 133, jcs242297. doi: 10.1242/jcs.242297
Valle-Tenney R, Rebolledo D.L., Acuña MJ, Brandan E. (2020) HIF-hypoxia signaling in skeletal muscle physiology and fibrosis. J Cell Commun Signal. 14:147-158.
Valle-Tenney R, Rebolledo D.L., Lipson K.E., Brandan E. (2020) Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers. Matrix Biol. 87:48-65
2019
Contreras O, Cruz-Soca M, Theret M, Soliman H, Tung LW, Groppa E, Rossi F.M., Brandan E. (2019) The cross-talk between TGF-β and PDGFRα signaling pathways regulates stromal fibro/adipogenic progenitors' fate. J Cell Sci. doi: 10.1242/jcs.232157.
Contreras, O., Rossi, F.M., Brandan, E. (2019) Adherent muscle connective tissue fibroblasts are phenotypically and biochemically equivalent to stromal fibro/adipogenic progenitors. Matrix Biol. Plus. Vol 2, Article 100006.
Gonzalez, D and Brandan, E (2019) CTGF/CCN2 from skeletal muscle to nervous system: impact on neurodegenerative diseases.
Mol. Neurobiol. In Press doi.org/10.1007/s12035-019-1490-9
Rebolledo, D.L., González, D., Faundez-Contreras, J., Contreras, O., Murphy-Ullrich, J.E., Lipson, K.E. and Brandan, E. (2019) CTGF/CCN2 Modulates Denervation-induced Skeletal Muscle Fibrosis independently of TGF-b. Matrix Biol. doi: 10.1016/j.matbio.2019.01.002.
2018
Gonzalez D, Rebolledo DL, Correa LM, Court F, Cerpa W, Lipson KE, van Zundert B, Brandan E (2018) The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum Mol Genet. 2018 May 30. doi: 10.1093/hmg/ddy204
Contreras, O., Villarreal, M. and Brandan, E. (2018) Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skelet Muscle 20;8(1):5.
Riquelme-Guzmán, C., Contreras O., and Brandan E. (2018) Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. Am. J. Physiol. Cell Physiol.314, C415-C427.
Acuña, MJ., Salas, D., Cordova-Casanova, A., Cruz-Soca, A., Céspedes, C, Vío, C.P. and Brandan, E (2018) Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors. J Cell Commun Signal. doi: 10.1007/s12079-017-0439-x.
Morales, M.G., Acuña, M.J., Cabrera, D., Goldschmeding, R and Brandan E. (2018) The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle. J Cell Commun Signal. doi: 10.1007/s12079-017-0409-3.
2017
Contreras O, Brandan E. (2017) Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. J Cell Commun Signal. (2017) 11:77-78.
Cabrera, D., Wree, A., Povero, D., Solis, N., Hernandez, A., Pizarro, A, Moshage, H., Torres, J., Feldstein, A., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. Arrese, M. (2017) Andrographolide ameliorates inflammation and fibrogenesis and attenuates inflammasome activation in experimental non-alcoholic steatohepatitis. Sci Rep. 14;7(1):349.1doi: 10.1038/s41598-017-03675-z.
Gonzalez, D., Contreras, O., Rebolledo, DL., Espinoza, JP., van Zundert, B., Brandan E. (2017) ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS One 16;12(5):e0177649. doi: 10.1371/journal.pone.0177649.
2016
Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. Contreras O, Brandan E. J Cell Commun Signal. (2016) Dec 20. doi: 10.1007/s12079-016-0372-4.
Contreras, O., Rebolledo, D.L. Oyarzún, J.E., Olguín, H. and Brandan, E. (2016) Connective tissue cells expressing fibro/adipogenic progenitors markers increase under chronic damage; Relevance to fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell Tissue Res. 364, 647-60.
Morales, M.G., Abrigo, J., Acuña, M.J., Santos, R., Bader, M, Brandan, E, Simon, F., Olgin, H., Cabrera, D. and Cabello-Verrugio, C. (2016). Ang 1-7 decreases muscle wasting by disuse. Dis Model Mech 9, 441-449.
Fuenzalida, M., Espinoza, C., Pérez, M.A. Tapia-Rojas, Ch., Cuitino, L., Brandan, E. Inestrosa, N.C. (2016) Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Neurobiol. Dis. 86, 109-20
Cabrera, D., Ruiz, A., Cabello-Verrugio, C., Brandan, E., Estrada, L., Pizarro, M., Solis, N., Torres, J., Barrera, F., and Arrese, M. (2016) Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1. Dig. Dis. Sci. DOI 10.1007/s10620-016-4285-0
Gutiérrez, J*., Droppelmann, CA., Contreras, O., Takahashi, C., and Brandan, E*. (2015) RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice. PLoS One 2015 Aug 6;10(8):e0135005. doi: 10.1371/journal.pone.0135005. (*Both corresponding authors).
Cofre, C., Acuña, M.J., Contreras, O., Morales, M.G., Riquelme, C., Cabello-Verrugio, C. and Brandan, E. (2015) Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies. BioFactors, 41, 111-20.
Passos-Silva, D., Brandan, E. and Souza Santos, RA. (2015) Angiotensins as therapeutic targets beyond heart disease. Trends Pharmacol. Sci. 36, 310-320
Córdova G, Rochard A, Riquelme-Guzmán C, Cofré C, Scherman D, Bigey P, Brandan E. (2015) SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth
Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β. J. Cell. Biochem. 116, 1880-7
Brandan E. (2015). Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion. J Cell Commun Signal. 9,89.
Cisternas, F., Morales, M.G., Meneses, C., Dimon, F., Brandan, E., Abrigo, J, Vazquez Y and Cabello-Verrugio, C. (2015). Angiotensin 1-7 Decreases Skeletal Muscle Atrophy induced by Angiotensin II through Mas Receptor Dependent Mechanism. Clin Sci (Lond). 128,307-19.
Meneses C, Morales MG, Abrigo J, Simon F, Brandan E, Cabello-Verrugio C.The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice. (2015) Pflugers Arch. 467, 1975-84.
2014
Acuña MJ, Pessina P, Olguin H, Cabrera D, Vio CP, Bader M, Muñoz-Canoves P, Santos RA, Cabello-Verrugio C, Brandan E. (2014). Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling.Hum Mol Genet. 23, 1237-49
Mol. Neurobiol. 49, 574-89.
2013
Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E. (2013). Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Hum Mol Genet. 15, 4938-512.