2020
Contreras, O., Soliman, H., Theret, M., Rossi, F.M., and Brandan, E. (2020) TGF-b-driven downregulation of the Wnt/b-Catenin transcription factor TCF7L2/TCF4 in PDGFRa+ fibroblasts. J. Cell Sci. 133, jcs242297. doi: 10.1242/jcs.242297
Valle-Tenney R, Rebolledo D.L., Acuña MJ, Brandan E. (2020) HIF-hypoxia signaling in skeletal muscle physiology and fibrosis. J Cell Commun Signal. 14:147-158.
Valle-Tenney R, Rebolledo D.L., Lipson K.E., Brandan E. (2020) Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers. Matrix Biol. 87:48-65
2019
Contreras O, Cruz-Soca M, Theret M, Soliman H, Tung LW, Groppa E, Rossi F.M., Brandan E. (2019) The cross-talk between TGF-β and PDGFRα signaling pathways regulates stromal fibro/adipogenic progenitors' fate. J Cell Sci. doi: 10.1242/jcs.232157.
Contreras, O., Rossi, F.M., Brandan, E. (2019) Adherent muscle connective tissue fibroblasts are phenotypically and biochemically equivalent to stromal fibro/adipogenic progenitors. Matrix Biol. Plus. Vol 2, Article 100006.
Gonzalez, D and Brandan, E (2019) CTGF/CCN2 from skeletal muscle to nervous system: impact on neurodegenerative diseases.
Mol. Neurobiol. In Press doi.org/10.1007/s12035-019-1490-9
Rebolledo, D.L., González, D., Faundez-Contreras, J., Contreras, O., Murphy-Ullrich, J.E., Lipson, K.E. and Brandan, E. (2019) CTGF/CCN2 Modulates Denervation-induced Skeletal Muscle Fibrosis independently of TGF-b. Matrix Biol. doi: 10.1016/j.matbio.2019.01.002.
2018
Gonzalez D, Rebolledo DL, Correa LM, Court F, Cerpa W, Lipson KE, van Zundert B, Brandan E (2018) The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Hum Mol Genet. 2018 May 30. doi: 10.1093/hmg/ddy204
Contreras, O., Villarreal, M. and Brandan, E. (2018) Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skelet Muscle 20;8(1):5.
Riquelme-Guzmán, C., Contreras O., and Brandan E. (2018) Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. Am. J. Physiol. Cell Physiol.314, C415-C427.
Acuña, MJ., Salas, D., Cordova-Casanova, A., Cruz-Soca, A., Céspedes, C, Vío, C.P. and Brandan, E (2018) Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors. J Cell Commun Signal. doi: 10.1007/s12079-017-0439-x.
Morales, M.G., Acuña, M.J., Cabrera, D., Goldschmeding, R and Brandan E. (2018) The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle. J Cell Commun Signal. doi: 10.1007/s12079-017-0409-3.
2017
Contreras O, Brandan E. (2017) Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. J Cell Commun Signal. (2017) 11:77-78.
Cabrera, D., Wree, A., Povero, D., Solis, N., Hernandez, A., Pizarro, A, Moshage, H., Torres, J., Feldstein, A., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. Arrese, M. (2017) Andrographolide ameliorates inflammation and fibrogenesis and attenuates inflammasome activation in experimental non-alcoholic steatohepatitis. Sci Rep. 14;7(1):349.1doi: 10.1038/s41598-017-03675-z.
Gonzalez, D., Contreras, O., Rebolledo, DL., Espinoza, JP., van Zundert, B., Brandan E. (2017) ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS One 16;12(5):e0177649. doi: 10.1371/journal.pone.0177649.
2016
Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. Contreras O, Brandan E. J Cell Commun Signal. (2016) Dec 20. doi: 10.1007/s12079-016-0372-4.
Contreras, O., Rebolledo, D.L. Oyarzún, J.E., Olguín, H. and Brandan, E. (2016) Connective tissue cells expressing fibro/adipogenic progenitors markers increase under chronic damage; Relevance to fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell Tissue Res. 364, 647-60.
Morales, M.G., Abrigo, J., Acuña, M.J., Santos, R., Bader, M, Brandan, E, Simon, F., Olgin, H., Cabrera, D. and Cabello-Verrugio, C. (2016). Ang 1-7 decreases muscle wasting by disuse. Dis Model Mech 9, 441-449.
Fuenzalida, M., Espinoza, C., Pérez, M.A. Tapia-Rojas, Ch., Cuitino, L., Brandan, E. Inestrosa, N.C. (2016) Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Neurobiol. Dis. 86, 109-20
Cabrera, D., Ruiz, A., Cabello-Verrugio, C., Brandan, E., Estrada, L., Pizarro, M., Solis, N., Torres, J., Barrera, F., and Arrese, M. (2016) Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1. Dig. Dis. Sci. DOI 10.1007/s10620-016-4285-0
Gutiérrez, J*., Droppelmann, CA., Contreras, O., Takahashi, C., and Brandan, E*. (2015) RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice. PLoS One 2015 Aug 6;10(8):e0135005. doi: 10.1371/journal.pone.0135005. (*Both corresponding authors).
Cofre, C., Acuña, M.J., Contreras, O., Morales, M.G., Riquelme, C., Cabello-Verrugio, C. and Brandan, E. (2015) Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies. BioFactors, 41, 111-20.
Passos-Silva, D., Brandan, E. and Souza Santos, RA. (2015) Angiotensins as therapeutic targets beyond heart disease. Trends Pharmacol. Sci. 36, 310-320
Córdova G, Rochard A, Riquelme-Guzmán C, Cofré C, Scherman D, Bigey P, Brandan E. (2015) SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth
Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β. J. Cell. Biochem. 116, 1880-7
Brandan E. (2015). Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion. J Cell Commun Signal. 9,89.
Cisternas, F., Morales, M.G., Meneses, C., Dimon, F., Brandan, E., Abrigo, J, Vazquez Y and Cabello-Verrugio, C. (2015). Angiotensin 1-7 Decreases Skeletal Muscle Atrophy induced by Angiotensin II through Mas Receptor Dependent Mechanism. Clin Sci (Lond). 128,307-19.
Meneses C, Morales MG, Abrigo J, Simon F, Brandan E, Cabello-Verrugio C.The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice. (2015) Pflugers Arch. 467, 1975-84.
2014
Acuña MJ, Pessina P, Olguin H, Cabrera D, Vio CP, Bader M, Muñoz-Canoves P, Santos RA, Cabello-Verrugio C, Brandan E. (2014). Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling.Hum Mol Genet. 23, 1237-49
Mol. Neurobiol. 49, 574-89.
2013
Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E. (2013). Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Hum Mol Genet. 15, 4938-512.